Arguably the Titans best player over the first eight rounds, Corey Thompson will miss up to two months after injuring his ankle in the local derby clash against the Broncos.
Titans High Performance Manager, Klint Hoare, confirmed that Thompson will need surgery.
"Unfortunately Corey Thompson has suffered a syndesmosis to his left ankle with an MRI confirming a multiple ligament injury.
"The best case scenario is an eight week return to play."
Thompson was the only injury to come out of the Titans round eight loss to the Broncos.
Anthony Don played his first game since round four after returning from a hip injury and Hoare says he has recovered well.
"In a physical match with the team's highest recorded high-speed running (HSR) in 2021, he was able to complete the full 80 minutes and has pulled up well."
There are four players on their way back from injury (Sam Stone, Sam Lisone, Jonus Pearson and Patrick Herbert) and they are progressing well through their rehab.
"Sam Stone is two weeks post a left ankle injury," Hoare said.
"He is going well and now at the end stage of rehab.
"He has integrated into skills with the aim to be available to this weekend for his Intrust Super Cup team (Burleigh Bears).
"Jonus is to have surgery with a meniscus repair required.
"This coincides with the original grade two MCL diagnosis and he is expected to return for round 15.
"Sam Lisone is currently in his second week of his phase one of his return to play program for his pectoral tear which he suffered in the game against South Sydney.
"Sam has an expected return of round 16.
"Patrick Herbert suffered a grade two calf strain (also in the game against South Sydney).
"He is expected back by round 13 when we take on the Melbourne Storm."
Tino Fa'asuamaleaui will return to the Titans side for the round nine clash against the Wests Tigers after missing the last two weeks through suspension.